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Plenary Lecture

In Silico Analysis of the Slow Delayed Rectifier K+ Current (IKs) in the Heart

Professor Péter P. Nánási
Department of Physiology
University of Debrecen
Hungary
E-mail: nanasi.peter@med.unideb.hu

Abstract: Since the role of IKs in ventricular repolarization is still a matter of long dispute, the performance of IKs during the plateau of a ventricular action potential was simulated. We compared the profile of the predicted current using three different mathematical models in order to determine the relative contribution of IKs to ventricular repolarization. The role of three independent variables: (1) pacing cycle length, (2) action potential duration, and (3) plateau height were simulated in three distinct layers of the ventricle: in (1) epicardiac, (2) midmyocardiac and (3) endocardiac cells of the canine myocardium. Results of these simulations were compared with experimental results obtained using voltage clamp measurements. It was concluded that the height of the action potential plateau is the most important determinant of the magnitude of IKs activated in mammalian myocardium. Accordingly, interspecies and regional differences observed in the efficacy of IKs blockers can be explained by the known differences in action potential morphology.

Brief Biography of the Speaker: Péter P. Nánási was born in 1956, at Debrecen, Hungary. He graduated from the University Medical School of Debrecen with an M.D. degree in 1980. He obtained his Ph.D. degree in 1992, and he received the D.Sc. degree from the Medical Branch of the Hungarian Academy of Sciences in 1999. From 1980, he has been working at the Department of Physiology, University of Debrecen - as a full professor since 2002. At the same time, he is the chairman of the "Department of Oral Physiology and Pharmacology" at the Faculty of Dentistry since 2001. During his career, he has spent 2 years in the United States, at the Children's Hospital Medical Center and at the Department of Pharmacology and Cell Biophysics, University of Cincinnati, Ohio with professors David A. Lathrop and Shirley H. Bryant. His research interest covers the physiology and pharmacology of cardiac ion channels, including the frequency-dependent interactions, regulation of action potential duration, and cellular mechanisms of antiarrhythmic and proarrhythmic actions. He is member of the Physiological Society, British Pharmacological Society, European Working Group on Cardiac Cellular Electrophysiology, MyoNaK, and the International Academy of Cardiovascular Sciences. He has published 119 full length papers (IF=310) and 6 book chapters in English language. He was also involved in more than 160 lectures and posters in the field of cellular cardiac electrophysiology.

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