Plenary Lecture

Double Compartment Cellular Automata Modeling of HIV Proliferation Under Plasmapheresis Treatment

Professor Yongwimon Lenbury
co-author: Sompop Moonchai
Department of Mathematics
Faculty of Science
Mahidol University
Bangkok, Thailand
E-mail: scylb@yahoo.com

Abstract: In this work, we apply the Monte Carlo Cellular Automata Simulation technique to study the dynamics of human immunodeficiency virus (HIV) proliferation and the action of virus-immune system in the human body in fighting the disease. Double-compartment model is utilized to take into account the blood as well as the lymph node compartments. Efficacy of treatments by plasmapheresis and its and combination with drug prescriptions are studied. We investigate the impacts of different treatment protocols on the ability of the infected patients to fight the development of AIDS symptoms. In particular, the possibility of interrupted or alternate treatment will be illustrated by CA simulations with appropriately chosen system parameters.

Brief Biography of the Speaker: After Professor Yongwimon Lenbury obtained her Ph.D. in Mathematics from Vanderbilt University, USA, she returned to the Department of Mathematics, Faculty of Science, Mahidol University to teach, and conduct research in dynamical modeling of nonlinear systems in biology and medicine. She was appointed professor of Mathematics in 1996. Prof. Lenbury has been involved in research work in the field by Mathematical Modelling and Nonlinear Systems in Biology and Medicine. Her work involves dynamical modelling and analysis of nonlinear systems such as food chains coupled by parasitic infections, hormone secretion systems in the human body, and so on. Of particular interest are the pacemaker oscillations and rhythmogenesis in human mechanism which have been proposed as a way to differentiate sickness from health. For example, some of her works involves the construction and analysis of a model for insulin kinetics and the identification of oscillatory behavior subject to various feeding regimens. Her recent interest has been concentrated in the signal transduction system involving GPCR, a major drug target. She received an award from the National Research Council as the Outstanding Researcher in the field of Physical Science in the year 1998. Her continued achievements have resulted in her being granted the prestigious position of Senior Researcher of the Thailand Research Fund in Mathematics, 2000-2002 and a Fellow of the Royal Institute of Thailand. Collaborating with several researchers in various countries such as the United States, Germany, Italy, and New Zealand, Prof. Lenbury has been devoted to the promotion of research and education in the field of Mathematics in Thailand.

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